The theory behind Polynucleotide Treatments is that the Polynucleotides interact with receptors on skin cells, which promotes the production of new collagen and elastin fibers. This can result in smoother, firmer, and more youthful-looking skin.
How To Use: Apply several times per week on dry skin as your first step, apply serum and night-time moisturizer over the top to occlude into the skin
Micro-needling: Apply to skin during micro-needling. LED is beneficial immediately after micro-needling and applying nighttime cream over Rejuran Polynucleotides.
Our Exclusive Polynucleotide Ampoule solution by Joli Visage offers highest quality, powerful molecules that transform the landscape of skincare technology, promising remarkable improvements in skin health and rejuvenation.
What are Polynucleotides?
Polynucleotides are long chains of nucleotides, which are the fundamental units of DNA and RNA. They play critical roles in storing and transmitting genetic information in biological systems. There are two main types of nucleotides: DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
DNA: DNA is the molecule that stores genetic information in living organisms.
RNA: RNA plays a crucial role in using the genetic information encoded in DNA to produce proteins. RNA molecules are involved in various cellular processes, including acting as a messenger between DNA and ribosomes, where proteins are synthesized.
From an aesthetic point of view, they play a crucial role in various biological processes, especially cellular skin repair and skin regeneration. Originally, Polynucleotides were utilized in medical therapies for their regenerative properties, particularly in wound healing and tissue repair.
Let's talk about the latest news on Polynucleotide Salmon Sperm Ampoule combined with Nano-needling or microneedling.
The first step in this home treatment is a gentle micro-needling or nano-needling on the face, neck and decollete. This treatment creates micro-channeling insuring ampoule
Solutions reach lower layers of the skin and considered to be a collagen induction therapy in itself. But the unique benefits of adding the 2nd step, many choices of ampoules by Joli Visage Skincare delivers a higher level of performance and skin results!
In layering the Polynucleotide Ampoule to the skin while using Derma Glow Hydra Infusion Nano Device, or any of our state-of-the-art micro needling or derma stamp device you are guaranteed to see visible changes in the skin.
Polynucleotide Ampoule Infusion:
The DNA Polynucleotides extracted from the Salmon Gonads are distilled, purified and mixed into a water formula.
These nucleotides undergo rigorous processing to ensure safety and effectiveness, with biotechnological advancements enabling the consistent synthesis of high-quality polynucleotides for anti-ageing treatments.
Popular in Korea, this advanced skincare technology aims to rejuvenate the skin by improving texture and elasticity, reducing fine lines, and brightening the complexion. Even celebrity Jennifer Aniston gets the Salmon Sperm Facials. Favored for their high purity and biocompatibility. These DNA Polynucleotides act as bio stimulants, promoting the activity of fibroblast cells in the skin, which boosts collagen and elastin production.
Mechanism of Polynucleotide Action in Skincare
As mentioned briefly earlier, polynucleotides stimulate fibroblast activity, promoting collagen and elastin production, essential for skin firmness and elasticity. They enhance cellular repair mechanisms, accelerating the healing of damaged skin tissues.
Beyond that are the significant anti-inflammatory effects, reducing redness, swelling, and irritation. These properties make them ideal for post-treatment care, minimising downtime and enhancing patient comfort.
Another ability of polynucleotides is their ability to improve skin hydration by enhancing the extracellular matrix (ECM), which retains moisture and provides structural support. Increased skin elasticity results in a more youthful and supple appearance.
Polynucleotides also help neutralize free radicals, reducing oxidative stress and preventing premature ageing. This antioxidant action protects the skin from environmental damage and promotes long-term skin health.
Increases Hydration and Smoothness
In clinical studies, skin hydration levels were increased, resulting in real, visible improvements in skin smoothness and texture.
Benefits of Polynucleotides in Aesthetic Treatments
Think polynucleotides, think smoother skin, reduced fine lines and wrinkles.
It may also help in reducing the appearance of superficial pigmentation and blemishes, resulting in a more youthful and uniform appearance. Continued use of polynucleotides can prevent the formation of new wrinkles by maintaining skin elasticity and hydration
How often should I perform the Polynucleotide Treatment with Nano-Needling
At home?
Typically, We recommend 1 treatment per week for home use.
Apply Blue Copper Peptide or EGF/KGF Ampoules after completing Nano-Needling
Followed by Spongilla Collagen Cream, or Reviving Collagen Serum
And Reviving Deep Wrinkle Cream immediately after your home treatment is finished.
What is the cost of one polynucleotide treatment? We offer in spa treatments at Jolie Day Spa for $250 per treatment.
We recommend a series of 4 treatments 2 weeks apart.
Are there any side effects related to polynucleotides?
Side effects are generally minimal, with temporary redness or swelling being the most common. Patients can expect improved skin texture, reduced wrinkles, and enhanced firmness, making polynucleotide treatments a popular choice for those seeking non-surgical skin rejuvenation options.
Article from https://www.sciencedirect.com/science/article/pii/S2096691122000723#sec3
Abstract
Polydeoxyribonucleotide (PDRN) consists of DNA fragments with molecular weights ranging from 50 to 1 500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many preclinical and clinical studies have demonstrated the properties of PDRN. These include anti-inflammatory, anti-apoptotic, anti-osteoporotic, anti-melanogenetic, anti-allodynic, anti-osteonecrotic, bone regenerative, tissue damage preventive, anti-ulcerative, and wound healing properties, which are mediated by the activation of the adenosine A2A receptor and salvage pathways. Moreover, PDRN promotes angiogenesis, cellular activity, collagen synthesis, soft tissue regeneration, and skin priming and revitalization and can be used to treat hyperpigmentation. Therefore, this review assessed the potential use of PDRN as an anti-aging agent for the skin.
Meso Filler-Stem Cell Net：200mg/5ml Material；Hyaluronic acid, collagen, fibroblasts, nucleotides, fibronectin Oligopeptide, serum protein
